Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...

Background and Objective: Semaglutide, a glucagon-like peptide 1 (GLP1a) receptor agonist, reduces the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus (DM2). An oral version of semaglutide is now available, and patients may prefer it to the subcutaneous form. Our objective was to compare the effectiveness and safety of both formulations in real life.Methods: Retrospective real-world efficacy analysis including aGLP1-...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

Introduction: Hydrocarbon Alteration (HA) is considered as the most common complication in Cystic Fibrosis (CF) and is related to a further deterioration of the lung function and the nutritional status.Objective: Analyze the prevalence of HA in patients with CF in an adult unit and its relationship with pulmonary complications.Material and methods: We conducted a retrospective study with 71 patients of our CF unit (age 30+/−9...

Introduction: Surgery is the treatment of choice for non-functioning pituitary adenomas (NFPA), but remnants are frequently observed. Management of these remnants include observation (OBS), radiotherapy (RT) and/or dopamine agonist (DA) therapy. In this study, we evaluate the progression-free survival (PFS) of NFPA with postoperative remnant and the potential factors involved.Methods: We performed a single-center ambispective study of a cohort of 72 pati...

Introduction: Funding of continuous glucose monitoring (CGM) has been established by Madrid Health Service for adults with type1 Diabetes Mellitus (DM) who meet specific criteria. This has brought to lightthe need foran increasedinvestment in care time. In our Division, a structured training program has been established, consisting of 2 training sessions (TS); the first one based on basic contents to initiateFlash-CGM, and the second one, more intensive and targeted, focused o...

Introduction: Neuroendocrine tumors (NETs) are rare and their clinical behavior and prognosis correlates with mitotic rate and Ki-67 index. Most patients with advanced NET have liver metastases unresectable and somatostatin analogues are the initial therapy of choice but when disease progresses despite treatment and there are positive somatostatin receptors, peptide receptor radioligand therapy (PRRT), using lutetium-177, is a therapeutic option.Clinical...

Introduction: In the treatment of amiodarone-induced type I or mixed thyrotoxicosis, sodium or potassium perchlorate is often associated to thionamides, when the latter are insufficient for a prompt control of thyroid hormone secretion. Perchlorate competes with iodine for entrance into the follicular cell, and also induces a discharge of iodine from these cells with each administration. We compare the effect of 3 different regimes of perchlorate with methimazole on control of...